PTEN and acute respiratory distress syndrome: In a mouse model of ALI, we found that deletion of PTEN expression in PTENM-KO mice reduced lung inflammatory response and its injury, evidenced by decreased lung interstitial congestion and inflammatory cell infiltration, as compared with WT followed by rHMGB1 treatment (Fig. 2a, b, 2.40 ± 0.55 vs. 4.31 ± 0.75, p < 0.01).