SPG11 and hereditary spastic paraplegia: For example, KIAA1840(SPG11) mutations may mimic ALS5 when muscle wasting is marked in absence of other complicated signs, or complex HSP in presence of cerebellar and cognitive signs (Stevanin et al. 2007b, 2008a; Orlacchio et al. 2010; Daoud et al. 2012; Romagnolo et al. 2014).