These include melanogenesis (hsa04916, P=3.34×10−10), the PPAR signaling pathway (hsa03320, P=1.83×10−9), the hedgehog signaling pathway (hsa04340, P=1.12×10−7), and glioma (hsa05214, P=4.26×10−7). This evidence concerns the gene PPARA and central nervous system cancer.