Hereditary angioedema (HAE) due to C1 Inhibitor (C1-INH) deficiency (C1-INH-HAE) is a rare autosomal dominant disease due to reduced C1-INH plasma levels (C1-INH-HAE type I) or to the presence of a dysfunctional C1-INH (C1-INH-HAE type II) [1]. This evidence concerns the gene SERPING1 and hyperinsulinemic hypoglycemia, familial, 4.