Given that Tim-3 expression in DSCs was significantly decreased in miscarriage compared with normal pregnancy, and stimulation of DSCs with ligands of different TLRs resulted in up-regulation of Tim-3 expression (Figure 3A and Figure S2A), we hypothesized that, during normal pregnancy, Tim-3 provides protection from TLR-mediated damage. The gene discussed is HAVCR2; the disease is Miscarriage.