In addition, Antho 50 caused down-regulation of the epigenetic integrator UHRF1, an anti-apoptotic protein which is overexpressed in many human cancer cells and plays an important role in the epigenetic silencing of various tumor suppressor genes including p16INK4A, hMLH1 and RB121, 22, 23, 40. The gene discussed is CDKN2A; the disease is neoplasm.