In addition, the antioxidant PEG-catalase inhibited also the Antho 50-induced Bad dephosphorylation, Bcl-2 and UHRF1 down-regulation and caspase 3 activation providing further evidence that ROS play a key role in the Antho 50-induced apoptosis in CLL cells. The gene discussed is BCL2; the disease is B-cell chronic lymphocytic leukemia.