Several reports have shown that polyphenolic compounds can increase ROS levels in human cancer cells, including leukemia and that this response is involved in the pro-apoptotic effect of red wine polyphenols, Aronia melanocarpa polyphenols and EGCG through UHRF1 down-regulation and caspase 3 activation in leukemia cells18, 19. This evidence concerns the gene CASP3 and leukemia.