HCVpp pseudotype virus, expressing both E1 and E2 glycoproteins from either the genotype 1a or 2a on the external surface, exhibited a decrease in RLU in cells expressing IFI6 protein as compared to control cells (Figure 1, panel D), suggesting that the expression of IFI6 had an inhibitory effect at an early step of HCV infection. The gene discussed is IFI6; the disease is infection.