A downstream mediator of the effects of TGFβ is tumor-secreted Jagged1, which activates Notch signaling on bone stromal cells to increase pro-osteolytic IL-6 - a process that can be blocked with a γ-secretase inhibitor [49], but it is not known whether γ-secretase inhibitors have bone-anabolic activity. This evidence concerns the gene TGFB1 and neoplasm.