EGFR and systemic lupus erythematosus: For instance, the EGFR copy number is elevated in non-small cell lung cancer [29], an elevated copy number of CCL3L1 is associated with lower susceptibility to HIV infection [30], and a low copy number of FCGR3B (the CD16 cell-surface immunoglobulin receptor) increases the susceptibility to systemic lupus erythematosus and similar inflammatory autoimmune disorders [27].