KRAS and colorectal carcinoma: Further analyses in mutant KRAS CRC cell lines, including the SW480 (KRASG12V), DLD1 (KRASG13D), and HCT116 (KRASG13D) lines, revealed that only miR-4689 potently suppressed both SRE and AP1 transcriptional activities in all tested mutated KRAS cell lines (Figure 2a).