In the pathway analysis, the TLR3-TRIF pathway was associated with HE2 (p = 0.035) and ME3 (p = 0.0176), the TLR7-MyD88 pathway and TLR8-MyD88 pathways were both associated with HE_any (p = 0.07; p = 0.039) and the combined TLR7-TLR8-MyD88 pathway was associated with presence of at least one HE symptom (p = 0.0458). The gene discussed is TLR8; the disease is hereditary elliptocytosis.