BCL2 and colorectal carcinoma: As a positive control, a high dose of HA14–1 resulted in maximal sensitivity to MPTP with similar CRC in control SSM and ischemic SSM, demonstrating in the presence of the high dose of HA14–1 that a saturated sequestration of bcl-2 led to a similar degree of the MPTP opening in control and ischemic SSM, suggesting that a major contribution to MPTP sensitivity by bcl-2.