The concentration of CRP increases when there is systemic inflammation.15 A high concentration of CRP is considered a risk factor for heart disease.15 A more sensitive CRP test, called a hs-CRP assay, is a promising marker of coronary heart disease.16 Although a trend of decreased plasma CRP levels was observed following 12 weeks of supplementation, the effect did not reach significance (P=.107). The gene discussed is CRP; the disease is heart disorder.