EIF4E and cancer: Previously we reported that reduced actin cytoskeleton dynamics upon depletion of pseudopod enriched AHNAK, Septin 9, eIF4E and S100A11 in metastatic cancer cells led to increased expression of the epithelial marker E-cadherin and loss of mesenchymal markers N-cadherin and vimentin, essentially reversing epithelial-mesenchymal transition (EMT) [18].