Specific growth factors such as epidermal growth factor (EGF), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and insulin-like growth factor (IGF) and their receptors have been shown to play a significant role in the oncogenesis, progression, and resistance to therapy in mesothelioma [30]. The gene discussed is IGF1; the disease is mesothelioma.