GPT and obesity due to melanocortin 4 receptor deficiency: When cases with obesity were evaluated according to presence of insulin resistance (when HOMA-IR threshold value was defined as 3.16), waist circumference was markedly increased in the group with insulin resistance (P<0.05), whereas no difference was defined in weight SDS, BMI SDS, epicardial adipose tissue thickness, alanine transaminase, high sensitive C-reactive protein, interventricular septum thickness and left ventricular mass (Table 4).