TNF and hepatocellular carcinoma: The first study that tested an effective strategy for the treatment of HCC with MDR, demonstrated that chemicals in combination with adriamycin (ADM), mitomycin, 5-fluoruracil (5-FU), mutant human tumor necrosis factor-α (rmhTNF-α) and hydroxyapatite nanoparticles (nHAPs), could be beneficial for the local treatment of advanced HCC in vitro and in vivo experimental conditions.