In a mouse model of hepatocellular carcinoma, they showed that the transduction of tumor cells with a recombinant adeno-associated virus (rAAV) expressing CCL21, or intra-tumoral injections of rAAV-CCL21, allowed extensive infiltration of the tumor site by CD11c+ DCs and activated CD3+ CD69+ T cells. The gene discussed is ITGAX; the disease is neoplasm.