CTAG2 and cancer: Ayyoub et al. for example demonstrated that DNA demethylation induced by 5-aza-2′-deoxycytidine (5-AZA-CdR) increased or induced mRNA expression of several cancer-testis antigens in sarcoma cell lines, including MAGE-A10, SSX, NY-ESO-1, and LAGE-1, resulting in increased tumor cell recognition by CTLs (147).