CD8A and neoplasm: For instance, DiLillo et al. demonstrated a higher growth of B16 melanoma and lung metastasis, associated with decreased numbers of both CD4+ and CD8+ effector T cells, in mice depleted in B cells using an anti-CD20 antibody as compared with wild-type mice, demonstrating the key role of B cells in the induction and maintenance of a protective anti-tumor cellular immunity (108).