In parallel, Hindley et al. showed in carcinogen-induced tumor-bearing mice that Treg depletion allowed the development of HEVs within tumors, associated with higher expression of LTα, LTβ, CCL19, CCL21, and CXCL13, higher CD8+ T-cell infiltration, and lower tumor growth (99). The gene discussed is CCL21; the disease is neoplasm.