IFNG and neoplasm: Finally, some tumor-infiltrating B-cell subsets may act as killer cells through the expression of granzyme B and TRAIL, induce a Th1 polarization via the secretion of IFNγ and to a lesser extend IL12p40, as well as present processed antigens to T cells through the expression of MHC class I, MHC class II, and costimulatory molecules, as demonstrated in hepatocellular carcinoma patients (127).