The majority of the PD cases are sporadic with only less than 10% of the cases related to mutations in genes such as PARK2, PARK7, PINK1, LRRK2 or SNCA (Polymeropoulos et al., 1997; Krüger et al., 1998; Zarranz et al., 2004). This evidence concerns the gene PRKN and Parkinson disease.