In addition to its well-established importance in development and cancer research, special attention has been paid to the role of Rb1 in tissue regeneration (Bakay et al., 2006; Wang et al., 2013), particularly auditory HC regeneration (Mantela et al., 2005; Sage et al., 2005, 2006; Weber et al., 2008). The gene discussed is RB1; the disease is cancer.