Increased miR-34a-5p correlated with decreased SYT1 and STX-1A in human Alzheimer’s disease (AD) brain. MiR-34a-5p down-regulated 20 min (Joilin et al., 2014) and 5 h after LTP induction (Ryan et al., 2012); not regulated 30 min or 2 h after LTP induction (Wibrand et al., 2012). This evidence concerns the gene SYT1 and early-onset autosomal dominant Alzheimer disease.