Previous studies have demonstrated that mitochondrial aldehyde dehydrogenase 2 (ALDH2) may be an important additional source of nitrite-derived NO in rat heart (Perlman et al., 2009) and the vasculature (Golwala et al., 2009), but whether the oxidative environment in the vasculature of HF patients may alter the role for ALDH2 remains unknown. The gene discussed is ALDH2; the disease is hydrops fetalis.