The APOE*3-Leiden.CETP (E3L.CETP) model is a well-established model for hyperlipidaemia and atherosclerosis, which, unlike Apoe−/− and Ldlr−/− mice, responds well to the lipid-lowering and anti-atherogenic effects of statins25, fibrates26 and niacin27. Here, APOE is linked to hyperlipidemia.