LDLR and atherosclerosis: However, activation of BAT in Ldlr−/− mice did neither reduce plasma TC and (V)LDL-C levels (Fig. 9h and Supplementary Fig. 3d), change messenger RNA levels of selected hepatic genes (Supplementary Table 1), nor reduce atherosclerosis development (Fig. 9i,j), nor did the SQRT of the lesion area correlate with the total plasma TG and TC exposure during the study (Fig. 9k,l).