To evaluate whether the observed Cat upregulation by TKI is Foxm1 dependent, we treated ALL cells with TKI and evaluated Cat expression in the presence and absence of Foxm1. Only the Foxm1-expressing ALL cells (Foxm1fl/fl +EV) were capable of upregulating Cat after 4 h TKI treatment (Fig. 5f). The gene discussed is CAT; the disease is acute lymphoblastic leukemia.