BCR and acute lymphoblastic leukemia: To further analyse the function and regulation of FOXM1 in pre-B ALL cells, we focused our analysis on BCR-ABL1-driven ALL as a model for high-risk ALL and transformed B-cell precursors from Foxm1fl/fl mice with BCR-ABL1 and then transduced these with a 4-OHT-inducible Cre (Cre-ERT2) or an empty vector (EV; ERT2).