On the basis of these findings and the observed selective advantage of FOXM1-expressing cells in the presence of TKI we had observed (Fig. 2e,f), we further investigated the function of FOXM1 in mediating TKI resistance and determined TKI responsiveness of BCR-ABL1-driven ALL cells in the presence and absence of Foxm1. This evidence concerns the gene FOXM1 and acute lymphoblastic leukemia.