We found that overexpression of OXR1 in neurons significantly delays dysregulation of genes that are involved in diverse molecular functions altered in ALS (Olsen et al., 2001; Yoshihara et al., 2002; Chen et al., 2010), including a striking delay in the inflammatory response (Figs 5–7). Here, OXR1 is linked to amyotrophic lateral sclerosis.