OXR1 and amyotrophic lateral sclerosis: Using pathway analysis of these genes, we found that overexpression of OXR1 influences a range of important pathogenic mechanisms that have been previously found to be deregulated in ALS (Fig. 5C) (Olsen et al., 2001; Yoshihara et al., 2002; Perrin et al., 2005; Ferraiuolo et al., 2007; Chen et al., 2010; Lincecum et al., 2010).