POU5F1 and viral infectious disease: Spatial clustering has also been reported between the Ifnb gene and NFKB-bound sites upon virus infection (Apostolou and Thanos 2008), between the Nanog locus and genes bound by pluripotency factors (Apostolou et al. 2013), for pluripotency factor (NANOG, POU5F1, and SOX2) binding sites in ESCs (de Wit et al. 2013; Denholtz et al. 2013), Polycomb-regulated genes (Denholtz et al. 2013), and for NFKB-regulated genes in response to TNF−alpha stimulation (Papantonis et al. 2010).