SIRT1 and metabolic disease: Because it has been shown the overexpression of SIRT1 will reduce the degree of hepatic steatosis in mice NAFLD models [72], activation of SIRT1 with resveratrol, a natural SIRT1 activator, protected against ER and IR stress and had positive effects on metabolic diseases, which is mediated by overexpression of oxygen-regulated protein 150.