MBD1 and lung cancer: On the other hand, association studies on polymorphisms of the MBD1 gene with human cancers revealed that MBD1 SNPs were not significantly associated with breast cancer, while two polymorphisms (rs125555 and rs140689) of MBD1 were significantly correlated with lung cancer risk, which supported the evidence that MBD1 contributes to the risk of cancer [27,28].