MBD1 and cancer: For instance, in a study of the differential expression of MeCP2_MBD proteins among 10 cancer cell lines, MBD1 showed the highest expression level in three colon cancer cell lines, MBD2 was expressed the highest in the Raji cell line (leukemia) and the MDA-MBD-231 cell line (breast cancer), in which MeCP2 was drastically reduced [62].