ESR1 and breast cancer: For example, ACOX-1 positivity was significantly correlated with shorter OS as well as clinicopathological characteristics, such as higher histologic grade (p = 0.006), ER negativity (p < 0.001), PR negativity (p < 0.001), and higher Ki-67 LI (p < 0.001), that are associated with poor prognosis in breast cancer patients.