The presence of pontin protein was found in 87 of 95 (91.6%) RCC samples, and pontin protein expression was highly expressed in 38 out of the 87 (43.7%) pontin-positive RCC patients, whereas only weak to moderate pontin staining was found in 8 of 14 (57.1%) tumor adjacent renal tissues. Here, RUVBL1 is linked to neoplasm.