Based on the ability of the signaling cascade to lower the apoptotic threshold, regulation of the MAPK module has been proposed as a novel approach to treat leukemia [38] as it increases the sensitivity to various apoptotic stimuli, such as DNA-damaging agents, with alteration of Bcl-2 anti-apoptotic activity at a post-translational level for cellular growth and survival [39]. The gene discussed is BCL2; the disease is leukemia.