Using multivariate regression (Table 3), log10 of plasma amylin as an outcome remained to be negatively associated with duration of diabetes (β = −0.18, SE=0.06, p=0.002) and insulin treatment (β= −0.49, SE=0.19, p=0.03) after adjusting for diabetes, age, gender, ethnicity, education, ApoE4, BMI, cardiovascular disease, stroke, creatinine, the lipid profile including cholesterol, LDL and HDL and diabetic medications. The gene discussed is APOE; the disease is diabetes mellitus.