In this report, we present experimental evidence that HIV-infection alone can enhance a well-coordinated expression of different types of Ca2 + release channels and kinases which have been shown to trigger overexpression of both fast and slow cardiac/fetal myosins together with a myosin light-chain kinase (MYH6-alpha, MYH7-beta and MYLK respectively) that are critical for the contraction and relaxation of heart muscles. The gene discussed is MYH14; the disease is HIV infectious disease.