While MYH6 and MYH7 have been associated with myocarditis, arrhythmias, heart failure, and related heart diseases in the non-HIV population groups (p = 8 × 10− 11), our studies have provide strong experimental evidence that HIV infection alone, without any co-infection or treatment can initiate an abnormal expression of novel myosin MYH6, MYH7 & MYLK proteins, involved in cardiomyopathy, arrhythmia and/or premature death (p = 0.000440). This evidence concerns the gene MYH14 and heart failure.