Interestingly, loss of Abd-B in larval germline spermatocytes and subsequent loss of βPS-integrin from the neighboring cyst cells is associated with cell non-autonomous effects in the GSCs surrounding the hub: GSC centrosomes are frequently mispositioned and GSC division rates are reduced, which results in a dramatic decline of pre-meiotic cell populations in adult testes. The gene discussed is HOXA9; the disease is cyst.