NAT2 and Hepatitis: A slow N-acetyltransferase 2 (NAT2) acetylator phenotype was found to be a significant risk factor for hepatitis.(25) In contrast, a rapid/intermediate NAT2 acetylator phenotype was found to be a protective factor for hepatotoxicity.(11,18) In addition, a C/C genotype at rs2070401 in BACH1 and a G/A or A/A genotype at rs4720833 in MAFK were found to be risk factors for drug-induced hepatotoxicity.(12)