NF-κB is found in almost all cell types involved in cellular responses to an extremely large variety of stimuli; it has NF-κB a key role in regulating the immune response to infection and – in turn – incorrect regulation of NF-κB has been linked to cancer, inflammatory, and autoimmune diseases, septic shock, viral infection, and improper immune development; it is also implicated in plasticity and cell survival (86)]. The gene discussed is NFKB1; the disease is cancer.