Dopaminergic deficits in the NS pathway may thus be a predisposing factor for AIP since schizophrenia patients with latent subclinical deficits in NS function would be more susceptible to external blockade of dopaminergic receptor, as happens in AIP (double hit model: underlying dopamine NS defect exaggerates DRD2 blockade). The gene discussed is DRD2; the disease is autoimmune pancreatitis.