SMAD7 and kidney disorder: These results are further supported by the results from in rodent models of obstructive and remnant kidney diseases induced in mice lacking Smad3, Smad7, or having conditional knockout (KO) for Smad2 or overexpressing renal Smad7 (Chung et al., 2010a, 2013a; Qin et al., 2011; Zhong et al., 2011).