CHD7 and small cell lung carcinoma: For instance, heterozygous mutation in the chromodomain helicase DNA binding protein 7 (CHD7) causes CHARGE syndrome, a multiple anomaly disorder that is a common cause of deaf-blindness in humans (Zentner et al., 2010), whereas duplication or overexpression of CHD7 is associated with multiple forms of cancer including colorectal cancer, pancreatic cancer, small-cell lung cancer, and gastric cancer (Pleasance et al., 2010; Kim et al., 2011; Colbert et al., 2014; Tahara et al., 2014).