Overgrowth disorders, Sotos syndrome and Weaver syndrome, are caused by heterozygous mutations in the HMT NSD1 (Sotos and Weaver syndromes) and EZH2 (Weaver syndrome) (Tatton-Brown and Rahman, 2013; Tatton-Brown et al., 2013). The gene discussed is EZH2; the disease is Weaver syndrome.