SOD1 and mild neurocognitive disorder: MND is a rapidly advancing degenerative condition where suitable new therapeutic strategies are badly needed (Turner and Talbot, 2008), so the pro-survival response produced by Fasudil in the SOD1 mouse model of MND is an impressive advance (Takata et al., 2013; Tonges et al., 2014) since the rapid progression of disease in this model generally does not respond to interventions (Turner and Talbot, 2008).