Although the amyloidogenic potential of the two β2-m species (WT and D76N) is in agreement with the concentration of the partially folded state at the equilibrium, a major and peculiar difference emerges from the clinical/pathological features of the two types of amyloidoses: notably, the localization in bones and ligaments of the WT and the visceral localization of the D76N. Here, B2M is linked to amyloidosis.