GATA-2, an important myeloid transcription factor, has been proven to be upregulated in CML CD34+ cells, whereas stem cell fate determination by the large family of Hox genes is negatively regulated by Bmi1 (Cao et al., 2005; Mohty et al., 2007). The gene discussed is BMI1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.