EIF4E and cancer: The eukaryotic translation initiation factor 4E (eIF4E) is a potent oncogene elevated in an estimated 30% of human cancers (Culjkovic et al., 2009; Siddiqui et al., 2012), and the eIF4E protein provides the critical interface between mRNA, recruitment of eIF4A and eIF4G, and the 40S ribosomal subunits.