BCL2 and chronic myelogenous leukemia, BCR-ABL1 positive: CML stem cell resistance to apoptosis involves the aberrant expression of the Bcl-2 family of apoptosis-regulatory proteins, including anti-apoptotic members, such as Bcl-2 and Mcl-1, and pro-apoptotic members, such as Bad and Bim (Bedi et al., 1994; Cramer et al., 2008).