BMI1 and chronic myelogenous leukemia, BCR-ABL1 positive: Studies have shown that the developmental pathways, such as the Wnt signaling pathway and the polycomb-group protein Bmi1, are involved in the regulation and expansion of LSCs during CML blast crisis (Chen et al., 1994; Reya et al., 2001; Saudy et al., 2014).