Though further in vitro and in vivo work has still to be done to understand the contribution of ABCA1, ACSL1, AGPAT1 and SCD in tumor progression, it is important to note that the prognostic prediction ability of this profile was confirmed in different sets of cancer patients, including an independent series of public gene expression microarray data of colon cancer patients from Gene Expression Omnibus Database, reinforcing the relevance of ColoLipidGene as a reliable prognostic tool in stage II colon cancer patients. The gene discussed is SCD; the disease is neoplasm.