ColoLipidGene, constituted by the combination of ABCA1, ACSL1, AGPAT1 and SCD, genes involved in lipid transport, fatty acid activation and phospholipid-related signaling, was able to significantly predict risk of relapse of CRC patients within the same stage II with a HR (95% CI): 4.65 (1.98–10.93), log-rank p < 0.001 (Figure 1). This evidence concerns the gene ACSL1 and colorectal carcinoma.