While it was found that NDRG2 and NDRG4 had opposing protein expression patterns when comparing normal brain tissue to glioblastoma tissue, suggesting the opposite function of NDRG4 to NDRG2, although NDRG4 is most similar to NDRG2 within the NDRG family [36, 38]. The gene discussed is NDRG4; the disease is glioblastoma.