NDRG4 and neoplasm: Statistical analysis results (Table 1) showed that NDRG4 positive staining was significantly associated with tumor well differentiation (P = 0.001), little invasiveness (P = 0.007), absent node metastasis (P = 0.004), absent distant metastasis (P = 0.001) and low TNM stage (P = 0.001), indicating NDRG4 might play tumor suppressive role in colorectal cancer by regulating tumor differentiation, invasion and metastasis.