FOXO1 and tongue cancer: We performed in situ hybridizations (ISH) to detect miR-491-3p and immunohistochemical staining to examine Rictor, p-Akt(Ser473), p-SGK1(Ser422) and p-FOXO1(Thr24) in the tissues from 84 tongue cancer patients who received chemotherapy based on PYM and/or cDDP.