MMP9 and cancer: Moro et al. found that loss of BRCA2 promoted prostated cancer cell invasion through up-regulation of matrix metalloproteinase-9 (MMP9), while downregulation of MMP-9 by inhibition of PI3K/AKT and activation of MAPK/ERKs suppressed cancer cell migration and invasion, limiting the metastatic potential of neoplastic cells [9].