FBN1 and ovarian carcinoma: Thus, FBN1 may indirectly suppress the expressions of E-cadherin, beta-catenin, and induce the expressions of MMPs through the TGF-beta-mediated signaling, although it is possible that FBN1 may function as a secretive matrix protein to interact with membrane receptors, which thereby activates additional signal pathways to regulate EMT and the expressions of these proteins in ovarian cancer cells.