TIMM8A and neoplasm: This group contains all negative regulators of the Akt/Tor pathway, many of which are known tumor suppressors in mammalian systems [39–41], and several negative regulators of the Mek/Erk pathway such as mts and wdb, encoding for components of the PP2a complex [42,43], and Mkp3, which encodes for a phosphatase known to negatively regulate Erk [44].