After immunohistochemical (IHC) staining of MMP-13 in melanoma tissues, 36 of 79 tumors were found to have high MMP-13 expression (MMP-13high) in tumor cells, whereas 43/79 tumors (including 11 with negative staining) had low MMP-13 expression (MMP-13low). Here, MMP13 is linked to neoplasm.