Reportedly, ECM remodeling by MMP-2 and MT1-MMP promotes VM formation in melanoma by cleaving the Ln-5 γ2-chain into the Ln-5 γ2′ and Ln-5 γ2x pro-migratory fragments, which can be molecular signals in the ECM microenvironment that induce concomitant expression of vascular-associated genes by melanoma cells. Here, MMP2 is linked to melanoma.