We found that formation of capillary-like tubes by A375 or B16-F10 melanoma cells on Matrigel was almost completely abolished after treatment with Ln-5 cleaved by MMP-13(2 μg/ml), whereas cells treated with exogenous Ln-5 or its MMP-2 cleavage fragments formed more typical vasculogenic-like and ECM-rich networks (Figure 4C). This evidence concerns the gene MMP2 and melanoma.