NFKB1 and posterior cortical atrophy: Since NF-kB pathway, especially p536 signaling is highly activated in T/E fusion expressing PCa, we hypothesize that p536 plays a critical, yet only partially understood, role in progression of PCas expressing the T/E fusion gene and that targeting NF-kB signaling in addition to traditional therapies may be more efficacious in this subgroup of PCa.