The SKIL rearrangements reported in this paper occurred in both untreated and castration resistant prostate cancers, and involved the 5′ partner genes TMPRSS2, SLC45A3, MIPOL1, ACPP, MIPEP and HMGN2P46. The androgen regulated genes TMPRSS2 and SLC45A3 are the most common 5′ partners involved in ETS fusions in prostate cancer [6]. Here, TMPRSS2 is linked to Familial prostate cancer.